Sfoglia per Autore "Miller, J. W."
Items 1-5 di 5
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Ancestry of the Timorese: Age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world
Morrison, M. A.; Magalhaes, T. R.; Ramke, J.; Smith, S. E.; Ennis, S.; Simpson, C. L.; Portas, L.; Murgia, F.; Ahn, J.; Dardenne, C.; Mayne, K.; Robinson, R.; Morgan, D. J.; Brian, G.; Lee, L.; Woo, S. J.; Zacharaki, F.; Tsironi, E. E.; Miller, J. W.; Kim, I. K.; Park, K. H.; Bailey-Wilson, J. E.; Farrer, L. A.; Stambolian, D.; DeAngelis, M. M. (2015)We observed that the third leading cause of blindness in the world, age-related macular degeneration (AMD), occurs at a very low documented frequency in a population-based cohort from Timor-Leste. Thus, we determined a ... -
Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach
Silveira, A. C.; Morrison, M. A.; Ji, F.; Xu, H.; Reinecke, J. B.; Adams, S. M.; Arneberg, T. M.; Janssian, M.; Lee, J. E.; Yuan, Y.; Schaumberg, D. A.; Kotoula, M. G.; Tsironi, E. E.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Miller, J. W.; Kim, I. K.; Hageman, G. S.; Farrer, L. A.; Haider, N. B.; DeAngelis, M. M. (2010)To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). ... -
FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic FLT1 Expression
Owen, L. A.; Morrison, M. A.; Ahn, J.; Woo, S. J.; Sato, H.; Robinson, R.; Morgan, D. J.; Zacharaki, F.; Simeonova, M.; Uehara, H.; Chakravarthy, U.; Hogg, R. E.; Ambati, B. K.; Kotoula, M.; Baehr, W.; Haider, N. B.; Silvestri, G.; Miller, J. W.; Tsironi, E. E.; Farrer, L. A.; Kim, I. K.; Park, K. H.; DeAngelis, M. M. (2014)PURPOSE. Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of ... -
Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology
Jun, G.; Nicolaou, M.; Morrison, M. A.; Buros, J.; Morgan, D. J.; Radeke, M. J.; Yonekawa, Y.; Tsironi, E. E.; Kotoula, M. G.; Zacharaki, F.; Mollema, N.; Yuan, Y.; Miller, J. W.; Haider, N. B.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; Farrer, L. A.; DeAngelis, M. M. (2011)ROBO1 is a strong candidate gene for age-related macular degeneration (AMD) based upon its location under a linkage peak on chromosome 3p12, its expression pattern, and its purported function in a pathway that includes ... -
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
Morrison, M. A.; Silveira, A. C.; Huynh, N.; Jun, G.; Smith, S. E.; Zacharaki, F.; Sato, H.; Loomis, S.; Andreoli, M. T.; Adams, S. M.; Radeke, M. J.; Jelcick, A. S.; Yuan, Y.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Silvestri, G.; Kotoula, M. G.; Tsironi, E. E.; Hollis, B. W.; Chen, R.; Haider, N. B.; Miller, J. W.; Farrer, L. A.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; DeAngelis, M. M. (2011)Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...